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Background: Skin autofluorescence is a non-invasive measurement of advanced glycation end products (AGE), which are suggested to be one of the major agents in the pathogenesis and progression of diabetes related cardiovascular complications. Recently, low vitamin D status has been linked to the progression of type 2 diabetes mellitus (T2DM) and cardiovascular disease.
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Vitamin D status is independently associated with skin auto fluorescence in patients with well-controlled T2DM, and no effect was seen on the amount of skin AGEs after a short period of 6 months vitamin D supplementation. BackgroundSkin autofluorescence is a non-invasive measurement of advanced glycation end products (AGE), which are suggested to be one of the major agents in the pathogenesis.
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We thank Bellastella et al. for their interest in our recently published double-blind, randomized, placebo-controlled trial in patients with type 2 diabetes who were treated with either vitamin D 3 (50,000 IU/month) or placebo for 6 months ().These patients were well controlled at baseline (HbA 1c was 6.8 ± 0.5% [51 ± 6 mmol/mol] and 6.8 ± 0.5% [51 ± 5 mmol/mol] in the vitamin D and.
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Krul-Poel YHM, Westra S, ten Boekel E, ter Wee MM, van Schoor NM, van Wijland H, et al. Effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes (SUNNY Trial): a randomized placebo-controlled trial. Diabetes Care. 2015 [Google Scholar]
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This trial will be the first study exploring the effect of vitamin D supplementation on both glycaemic control and quality of life in patients with type 2 diabetes mellitus, and will contribute to the knowledge of the relationship between vitamin D status and insulin resistance in patientswith type 2abetes mellitus. BackgroundBesides the classical role of vitamin D on calcium and bone.
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25972575 10.2337/dc15-0323 Low vitamin D status has been associated with impaired glycemic control in patients with type 2 diabetes. The purpose of our study was to evaluate the effect of vitamin D supplementation on glycemic control in patients with type 2 diabetes.
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Growing number of research studies have shown that an anti-ageing gene Klotho (KL) is closely associated with Type 2 Diabetes Mellitus (T2DM).In this study, the association is genetically analyzed with single nucleotide polymorphism (SNP) of KL found in T2DM case of an Asian cohort.KL SNP information was obtained from a big database of the Korean Association Resource (KARE) from which 20 KL.
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However, in a small subgroup of patients with severe vitamin D deficiency [serum 25(OH)D <30 nmol/L], a small but statistically significant decrease in HbA 1c was seen. In a similar intervention study (), the influence of vitamin D supplementation (Vigantol oil once a week corresponding to a daily dose of 1,904 IU vitamin D) in patients with noninsulin-requiring type 2 diabetes suggests the.
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Krul-Poel, YHM, Ter Wee, MM, Lips, P & Simsek, S 2017, ' The effect of Vitamin D supplementation on glycaemic control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis ', European journal of endocrinology, vol. 176, no. 1, pp. R1-R14.
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We read with interest the article by Krul-Poel et al. (1) that reported the results of a randomized controlled trial on the effect of vitamin D supplementation
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Krul-Poel et al. provided elegant evidence that vitamin D supplementation had no significant effect on insulin secretion, insulin sensitivity, and glycemic control in patients with type 2 diabetes.This randomized controlled trial (RCT) enrolled subjects with type 2 diabetes and vitamin D insufficiency, i.e., a cohort that according to previous studies should take advantage from vitamin D.
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In another study of 245 patients with type 2 diabetes,. Krul-Poel et al. also found that serum vitamin D status was inversely associated with skin autofluorescence in patients with.
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As many as 10% of patients diagnosed with Type 2 diabetes might actually have LADA, said Jason Gaglia, an endocrinologist at the Joslin Diabetes Center in Boston. Deroze and three other LADA.
